IP2 Accelerates CCS-enabled 4D-Proteomics™ with GPU-based Scalable Search Engine
IP2 Adds ‘Run & Done’ Real-Time Capabilities to timsTOF® Proteomics Systems
Bruker Corporation (Nasdaq: BRKR) announces the recent acquisition of the Integrated Proteomics Pipeline (IP2) search engine and proteomics workflow software platform. IP2 was developed by Integrated Proteomics Applications Inc, a company founded by leading proteomics researcher Professor John Yates III, together with Drs. Robin Park and Tao Xu. Financial details of the transaction were not disclosed.
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Prof. John Yates III, The Scripps Research Institute (Photo: Business Wire)
This acquisition further enhances Bruker’s solutions for CCS-enabled 4D-Proteomics™ by adding fast, scalable and GPU-based search engine capabilities for faster data processing and full utilization of molecular collision cross sections (CCS). Benefits include greater data completeness and higher confidence in protein and PTM identification and quantification in unbiased ‘shot-gun’ proteomics. Bruker’s novel timsTOF mass spectrometry systems with >120 Hz duty cycle in PASEF mode are uniquely suitable for real-time search by GPU-enabled, parallel operations on multiple threads.
“Partnering with the IP2 team and the Yates Lab provides an excellent opportunity to enhance Bruker’s bioinformatics capabilities in support of 4D-Proteomics™,” said Dr. Rohan A. Thakur, Bruker’s Executive Vice President for Life Science Mass Spectrometry. “High-throughput proteomics requires unprecedented search engine performance, including the need for low false discovery rates with very large datasets. This will benefit the proteomics research and translational medical community. We are also pleased to announce the establishment of Bruker’s bioinformatics team focused on protein and data science based in San Diego, California, headed by Robin Park who joined Bruker as part of the IP2 asset acquisition. Robin will continue to work closely with the Yates Lab in his new role with Bruker, as well as with other